Insulin Pump Therapy: Evidence Based Medicine

Insulin Pump Therapy: Evidence Based Medicine

Saeid Kalbasi, MD

Associate Prof. of Endocrinology and Metabolism

Shahid Beheshti University of Medical Sciences

Research Institute of Endocrine Sciences

What is an insulin Pump?

• It is a pager sized, battery operated device.
• It provides a continuous  insulin delivery over the 24 hours via a thin plastic tube    ( infusion set) with a soft cannula at the end inserted subcutaneously. 
•  Insulin delivery is programmed with an individualized  and unique plan suitable for each patient.

Pharmacokinetic Advantages

• Uses only Short Acting Insulin
  • More predictable absorption than with modified insulins (variation 3-7% vs 20-50%*)
• Uses one injection site for 2 to 3 days
  • Reduces variations in absorption due to site rotation
• Eliminates most of the subcutaneous insulin depot
• Programmable delivery allows closest match with physiologic needs